GRAPEFRUIT JUICE AND LISINOPRIL UPDATE

Furthermore, there are some medications that are affected by grapefruit in such as way that their absorption is increased leading to medication toxicity and over-dosage. It can either decrease the total drug serum levels or prolong the time needed for the medication take effect. So if Lisinopril & Grapefruit are ok, why is Grapefruit not recommend with other drugs?īasically, grapefruit contains potent chemicals that can affect or block the absorption of a lot of medications. For more specific information, you should consult your physician. Generally, doctors advise their patients to consult them first before taking any high acidic fruits, vegetables and other food products with your medication. A number of psychotropic drugs, including those used treat anxiety, depression, and psychosis, are among the agents grapefruit juice may interact with.1 This is because grapefruit contains furanocoumarins, an organic compound that blocks an enzyme that normally breaks down certain medications. If that is the case with you or someone you know, then grapefruit should not consumed. These types of medications are known to interact with grapefruit. People who are prescribed Lisinopril are often, also prescribed other medications concurrently such as statins and angiotensin II receptor antagonists. Some would warn you about the negative effects of taking lisinopril and grapefruit while others would not really mention any untoward interactions between these compounds.īecause of the varying recommendations, it is recommended that you consult your physician whether you should avoid grapefruit or not while on lisinopril. If you ask a group of physicians prescribing lisinopril, you’d likely get different opinions. Healthcare providers, too, have contrasting opinions when it comes to lisinopril and grapefruit. While these claims do not have substantial evidence and background studies, it is best to be warned and stay safe. However, there are some resources suggesting that grapefruit could potentially increase the patient’s blood pressure (contradicting the desired effect of lisinopril which is to lower blood pressure). Since there are no proven studies that show interaction between grapefruit and lisinopril, you can theoretically consume grapefruit while on lisinopril treatment without any adverse effects. Should grapefruit be avoided when taking lisinopril?Īt present, there are no studies that prove any interaction between grapefruit juice and ACE-inhibitors including lisinopril although such drug-food interaction is possible with another group of medications closely linked with ACE-inhibitors – the angiotensin II type receptor antagonists (such as losartan and valsartan). may also interact with certain foods or drinks, like grapefruit juice and alcohol. One commonly asked question by consumers is whether or not they can safely consume Grapefruit, grapefruit juice and other grapefruit products while on Lisinopril. ACE inhibitors are used for many heart and blood vessel problems. Like any other medications, lisinopril has some known drug and food interactions hence, taking these substances together must be avoided. ACE inhibitors relax the blood vessels by blocking the production of a vital chemical called angiotensin-converting enzyme. Small studies have shown that grapefruit juice may lower clopidogrel levels in the body. In brief: fexofenadine (allegra) and fruit juice.Lisinopril belongs to a group of medication called angiontensin-converting enzyme (ACE) inhibitors. By the way, doctor: Is it okay to drink grapefruit juice, as long as I don't take my statin at the same time?

Harvard Health Publishing, Harvard Medical School. Portland, OR: Oregon Health & Science University. Fruit juice, organic anion transporting polypeptides, and drug interactions in psychiatry. There are many medications and foods that can interact with buspirone. Amlodipine has been shown to raise blood levels of DHEA-sulfate in insulin-resistant, obese men with high blood pressure.

GRAPEFRUIT JUICE AND LISINOPRIL UPDATE

Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review. 9 Buspirone Interactions You Should Know About Written by Kristine Foley, PharmD Reviewed by Alyssa Billingsley, PharmD Published on NovemKey takeaways: Buspirone is a medication that’s FDA approved to treat anxiety. New York, NY: Elsevier Health Sciences.Ĭhen M, Zhou SY, Fabriaga E, Zhang PH, Zhou Q. Intestinal drug interactions mediated by OATPs: a systematic review of preclinical and clinical findings. Yu J, Zhou Z, Tay-sontheimer J, Levy RH, Ragueneau-majlessi I.

Grapefruit juice and lisinopril